TB-403 in paediatric brain tumours - development in collaboration with Oncurious, subsidiary of ThromboGenics
TB-403 is a humanised antibody directed against the PlGF protein, which is believed to inhibit its signaling via the Nrp-1 receptor. PlGF is expressed in patients with medulloblastoma, Ewing’s sarcoma, neuroblastoma and alveolar rhabdomyosarcoma.
TB-403 is currently in a Phase I/II study for the treatment of patients with medulloblastoma in cooperation with a US based pediatric oncology network, Neuroblastoma and Medulloblastoma Translational Research Consortium. The study is ongoing and the first dosage level with three patients has been finished.
TB-403 has recently received Orphan Drug Designation for medulloblastoma from the European Medicines Agency.
BioInvent has a 40% equity stake in TB-403, developed in conjunction with Oncurious. This is the result of a collaboration agreement signed in 2004 with Oncurious’ parent company ThromboGenics. Under the terms of the agreement BioInvent pays 50% of development costs of TB-403.
Patents for TB-403 and similar antibodies have been granted in Europe, the US, Japan and several additional countries, and patent applications are pending in further countries. Patents covering use of antibodies against PIGF, for example for the purpose of treating or preventing cancer, have also been granted, including in the US.