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BioInvent - translating cancer antibody biology into innovative immuno-oncology therapies.

BioInvent is generating value for shareholders by employing its antibody and cancer biology expertise to identify antibodies with novel mechanisms-of-action and novel oncology targets. The Company employs this approach to generate therapeutic immuno-modulating antibodies that can be developed for a broad range of cancer indications. The Company plans to bring these antibodies to the clinic through its own resources and together with partners.

To achieve these goals the Company is currently:

  • Progressing clinical development of our lead antibody BI-1206 for treatment of haematological cancers.
  • Advancing our innovative pre-clinical Treg immuno-oncology programmes identifying antibodies to novel targets and with novel functions as well as antibodies that address validated targets such as OX40 and 4-1BB.
  • Developing a pre-clinical portfolio of first-in-class antibodies targeting tumour-associated myeloid cells in collaboration with Pfizer.
  • Collaborating with Oncurious on the development of TB-403, a potential treatment for paediatric brain cancers.
  • Generating further revenues through antibody contract manufacturing and technology deals.

Immuno-oncology drugs can revolutionise treatment of cancer

The body’s immune system detects and destroys bacteria and viruses that would otherwise harm our organs and tissues. However, the immune system also has the potential to protect us from and fight cancer. Unfortunately, many tumour cells have the ability to manipulate important cells in our immune system in order to continue to multiply.

While chemotherapy is aimed directly at the tumour cells, immuno-oncology drugs activate important cells in the immune system (especially T-cells), and stimulate them to attack tumours. Immuno-oncology drugs are one of the greatest breakthroughs of the twenty-first century in the field of medicine.

They are making an important contribution in transforming the treatment of cancer through significant improvements in survival rates. However currently available immune modulatory drugs are only able to help a fraction of all cancer patients. Commercially, immuno-oncology therapies are expected to continue to be a success, with estimated sales to exceed USD 40 billion by 2022, according to the Cowen 2017 Therapeutic Categories report.

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Checkpoint Inhibitors

A special type of molecule known as checkpoints can be found on the surface of our white blood cells. Checkpoints function as a kind of switch to activate or deactivate the immune system. In some cases cancer cells manipulate these proteins to avoid attacks. For the past few years, immuno-oncology drugs have been used that are capable of inhibiting the checkpoint receptors PD-1, PD-L1 and CTLA-4. They have produced good treatment in certain types of solid tumours and achieved great commercial success, but unfortunately they only help a minority of patients with metastatic cancer. Consequently, intense efforts are underway to develop new drugs that can complement the checkpoint inhibitors in order to improve survival.

BioInvent strives to contribute to the development of more effective cancer treatments. The Company occupies a prominent position within the understanding of the biological and immunological aspects of cancer treatment and has a unique platform for identifying and developing new types of antibodies against the relevant target structures.

BioInvent is developing antibodies specific for regulatory T-cells and tumour-associated myeloid cells, both of which are expected to have synergies in combination with currently available checkpoint inhibitors.

Five focus areas for our value creation

BioInvent’s strategy is to leverage its expertise in antibodies and cancer biology to develop immuno-oncology drugs that significantly improve the treatment of cancer diseases. This is accomplished through collaborations with large pharmaceutical companies, academic research groups, networks of clinical specialists and research foundations. The goal is to create value for the Company’s shareholders based on successful drug development and subsequent revenue streams from existing and future commercial partners.

Five focus areas are deemed essential to the Company’s continued success – high-level science, professional product development, commercial focus, good risk management and financial sustainability.